Neural reprogramming via microRNAs: the new kid on the p53-deficient block

oleh: Deborah A. Silverman, George A. Calin, Jeffrey N. Myers, Moran Amit

Format: Article
Diterbitkan: Taylor & Francis Group 2020-07-01

Deskripsi

We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming in the tumor microenvironment which enhanced tumor growth.