Neural reprogramming via microRNAs: the new kid on the p53-deficient block
oleh: Deborah A. Silverman, George A. Calin, Jeffrey N. Myers, Moran Amit
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2020-07-01 |
Deskripsi
We recently reported a novel role for nerve-cancer crosstalk, demonstrating that tumor protein p53 (TP53) deficiency in head and neck squamous cell carcinoma leads to a decrease in miR-34a in tumor-shed vesicles. This directed sensory nerve reprogramming in the tumor microenvironment which enhanced tumor growth.