A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells
oleh: Giulia Bertolin, Florian Sizaire, Gaëtan Herbomel, David Reboutier, Claude Prigent, Marc Tramier
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
Alterations in aurora kinase A (AURKA) activity can result in mitotic errors and have been associated with cancer progression. Here the authors develop a FRET biosensor which functionally replaces AURKA in cells, and show that its activation in the G1 phase is required to maintain microtubule stability.