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ABSTRACT Human dirofilariasis is a zoonotic disease which is caused by the filarial nematodes, Dirofilaria repens and Dirofilaria immitis. Dirofilariae are transmitted to humans via mosquito bites. Human Dirofilariasis presents commonly as subcutaneous nodules, pulmonary nodules or nodules in the eyes. They are considered as emerging pathogens. We are presenting a case of human Dirofilariasis from Karnataka, which was caused by Dirofilaria repens.