Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report
oleh: Emna Haddad, MD, Benjamin Bottet, MD, Pierre-Alain Thiebaut, MD, PhD, Samira Morin, MD, Hélène Dreyfus, MD, Élise Vannier, MD, Colette Vincent, MD, Florent Marguet, MD, PhD, Aude Lamy, PhD, Hagay Sobol, MD, PhD, Jean-Marc Baste, MD, PhD, Florian Guisier, MD, PhD, Jean-Christophe Sabourin, MD, PhD, Nicolas Piton, MD, PhD
| Format: | Article |
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| Diterbitkan: | Elsevier 2024-01-01 |
Deskripsi
Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly colorectal and uterine cancers. However, cancers with microsatellite instability outside this spectrum, for example, lung cancer, are extremely rare. Here, we report a case of squamous cell carcinoma of the lung with microsatellite instability in a patient with Lynch syndrome.