Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization
oleh: Fátima C. Pereira, Kenneth Wasmund, Iva Cobankovic, Nico Jehmlich, Craig W. Herbold, Kang Soo Lee, Barbara Sziranyi, Cornelia Vesely, Thomas Decker, Roman Stocker, Benedikt Warth, Martin von Bergen, Michael Wagner, David Berry
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
Here, the authors employ Raman-Activated Cell Sorting (RACS) and metagenomics to identify organisms that can forage on O-glycan monosaccharides in the mouse gut, which they use to construct a bacterial consortium able to reduce Clostridioides difficile colonization based on competition for mucosal sugars.