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Roberto de Sire,1 Nicola Imperatore,1,2 Maria D’Armiento Snr,3 Pietro Coccoli,1 Imma Di Luna,1 Simona Ricciolino,1 Fabiana Castiglione,1 Antonio Rispo1 1Gastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy; 2Gastroenterology and Endoscopy Unit, AORN Antonio Cardarelli, Naples, Italy; 3Pathology, Department of Public Health, University Federico II of Naples, Naples, ItalyCorrespondence: Roberto de SireGastroenterology Unit, Department of Clinical Medicine and Surgery, University “Federico II” of Naples, Via Pansini 5, Naples, 80131, ItalyEmail roberto.desire@libero.itAbstract: Sclerosing mesenteritis (SM) is an idiopathic disorder affecting mesentery, characterized by fat necrosis, chronic inflammation and fibrosis. The clinical presentation varies from asymptomatic cases to acute abdomen. The diagnosis is suggested by imaging but can be definitely established only by biopsies. In this paper, we discuss ultrasonography-based management of SM.Keywords: sclerosing mesenteritis, mesenteric lipodystrophy, mesenteric panniculitis, retractile mesenteritis, ultrasonography