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The cell wall is the first interface for <i>Candida albicans</i> interaction with the surrounding environment and the host cells. Therefore, maintenance of cell wall integrity (CWI) is crucial for <i>C. albicans</i> survival and host-pathogen interaction. In response to environmental stresses, <i>C. albicans</i> undergoes cell wall remodeling controlled by multiple signaling pathways and transcription regulators. Here, we explored the role of the transcription factor Sfp1 in CWI. A deletion of the <i>SFP1</i> gene not only caused changes in cell wall properties, cell wall composition and structure but also modulated expression of cell wall biosynthesis and remodeling genes. In addition, Cas5 is a known transcription regulator for <i>C. albicans</i> CWI and cell wall stress response. Interestingly, our results indicated that Sfp1 negatively controls the <i>CAS5</i> gene expression by binding to its promoter element. Together, this study provides new insights into the regulation of <i>C. albicans</i> CWI and stress response.