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In the present study, a 63-year-old patient with no history of immunodeficiency was described. Accordingly, he referred to our center with fever, sweating, shaking chills, cough, and retrosternal chest pain that started three weeks ago. Pre-operative CT scan revealed a cystic mass with peripheral enhancement in the anterior mediastinum. The patient underwent open thoracic surgery and as a result, an infected thymic cyst was seen which was confirmed by performing pathologic examinations after resection.