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Background and objective Lung cancer has become one of the most dangerous malignant tumor in the world nowadays, whose pathogenesis is complex involving multi-genes and multi-elements. In this study, we try to explore the values of serum SYK and vascular endothelial growth factor-C (VEGF-C) in lymph node metastasis of lungadenocarcinoma. Methods Serum SYK and VEGF were examined in 160 lung adenocarcinoma patients with various metastasis lesions and 40 healthy volunteers by ELISA. Results The serum SYK level of the lung adenocarcinoma patients were remarkably lower than those of normal persons (P <0.05); The SYK level decreased while the lymph nodes areaincreased along with their metastasis (P <0.05), and the serum VEGF-C level were remarkably higher than those of healthy objects (P <0.05). The VEGF-C level increased with the increase of lymph nodes metastasis (P <0.05). For the serum level of SYK and VEGF-C, there was no statistical difference in sex and age (P <0.05). Negative correlation was found between SYK and VEGF-C (r =0.650, P <0.05). Conclusion The serum level of SYK and VEGF-C are closely related to the lymph nodes metastasis of lung adenocarcinoma. Combination detection of SYK and VEGF-C might be helpful for the predict oflymph nodes metastasis of lung adenocarcinoma.