Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
oleh: Stephan Brouwer, Timothy C. Barnett, Diane Ly, Katherine J. Kasper, David M. P. De Oliveira, Tania Rivera-Hernandez, Amanda J. Cork, Liam McIntyre, Magnus G. Jespersen, Johanna Richter, Benjamin L. Schulz, Gordon Dougan, Victor Nizet, Kwok-Yung Yuen, Yuanhai You, John K. McCormick, Martina L. Sanderson-Smith, Mark R. Davies, Mark J. Walker
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-10-01 |
Deskripsi
The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal colonization in mice.