mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1

oleh: Yushen Du, Judd F. Hultquist, Quan Zhou, Anders Olson, Yenwen Tseng, Tian-hao Zhang, Mengying Hong, Kejun Tang, Liubo Chen, Xiangzhi Meng, Michael J. McGregor, Lei Dai, Danyang Gong, Laura Martin-Sancho, Sumit Chanda, Xinming Li, Steve Bensenger, Nevan J. Krogan, Ren Sun

Format: Article
Diterbitkan: Nature Portfolio 2020-05-01

Deskripsi

Identification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A virus, and show that one interactor provides a means to regulate cellular fatty acids synthesis.