T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy
oleh: Colin Denis, Kevin Dabbs, Veena A. Nair, Jedidiah Mathis, Dace N. Almane, Akshayaa Lakshmanan, Andrew Nencka, Rasmus M. Birn, Lisa Conant, Colin Humphries, Elizabeth Felton, Manoj Raghavan, Edgar A. DeYoe, Jeffrey R. Binder, Bruce Hermann, Vivek Prabhakaran, Barbara B. Bendlin, Mary E. Meyerand, Mélanie Boly, Aaron F. Struck
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2023-11-01 |
Deskripsi
Abstract Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age‐matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group‐level aberrations in overall myelin content or myelin changes through time in TLE.