Correlations of MGMT promoter methylation and IDH1 mutations with the clinical prognosis of malignant glioma patients
oleh: ZHANG Ning, MA Hui-hui, WANG Fan, LIANG Wei, WANG Yi-chun, WU Bing-shan, LI Qing-xin
| Format: | Article |
|---|---|
| Diterbitkan: | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2021-10-01 |
Deskripsi
Objective To analyze retrospectively the IDH1 mutation and MGMT promoter methylation of malignant glioma patients and to identify potential relation to clinical situation. Methods Twenty-five patients with glioma who were received treatment from October 2017 to October 2019 were selected; the survival rate was calculated by Kaplan-Meier method and analyzed by Log-Rank test. Results Univariate analysis showed that negative status of MGMT gene promoter methylation(χ2=4.22,P＜0.05) was an important factor affecting the survival rates of patients, and patients with both negative status of MGMT gene promoter methylation and mutation of IDH1 had a significantly prolonged survival(P＜0.05). Conclusions IDH mutation and MGMT promoter methylation status are significantly related to the prognosis of malignant glioma patients.