Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
oleh: Ana L. Legarda-Ceballos, Esther del Olmo, Julio López-Abán, Ricardo Escarcena, Luis A. Bustos, Cristina Fonseca-Berzal, Alicia Gómez-Barrio, Juan C. Dib, Arturo San Feliciano, Antonio Muro
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2015-06-01 |
Deskripsi
Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0–6.6 times) than the reference compound nifurtimox. From them, three aminoalcohols and two diamines were selected for amastigotes assays. Compound 5 was as potent as the reference drug nifurtimox against amastigotes of the CL-B5 strain (IC50 = 0.6 µM), with a selectivity index of 54.