Selective single molecule sequencing and assembly of a human Y chromosome of African origin
oleh: Lukas F. K. Kuderna, Esther Lizano, Eva Julià, Jessica Gomez-Garrido, Aitor Serres-Armero, Martin Kuhlwilm, Regina Antoni Alandes, Marina Alvarez-Estape, David Juan, Heath Simon, Tyler Alioto, Marta Gut, Ivo Gut, Mikkel Heide Schierup, Oscar Fornas, Tomas Marques-Bonet
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chromosome of African origin.