Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
oleh: H. M. York, A. Patil, U. K. Moorthi, A. Kaur, A. Bhowmik, G. J. Hyde, H. Gandhi, A. Fulcher, K. Gaus, S. Arumugam
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
York et al employ lattice light-sheet microscopy to study the initial events following activation of the epidermal growth factor receptor (EGFR) in whole live cells. They find that APPL1 relocates from pre-existing endosomes, triggered by calcium, to EGFR puncta which results in a cohort, dynein mediated movement of EGFR towards the peri-nuclear region of the cell, expanding our understanding of EGFR trafficking dynamics.