Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
oleh: Jinping Liu, Alex Kruswick, Hien Dang, Andy D. Tran, So Mee Kwon, Xin Wei Wang, Philipp Oberdoerffer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-07-01 |
Deskripsi
BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.