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A morphometric evaluation of thyroid papillary carcinoma was carried out, with the objective of identifying possible morphometric parameters that contribute to precise its histological diagnosis. A number of 32 diagnosed biopsies of the University Hospital “Celestino Hernández Robau”, from Santa Clara were studied. Nuclear morphometric variables were determined, such as, area, perimeter, range and shape factor, by means of COMSDI PLUS version 1.0 computing program. Papillary carcinoma in its non classical histological variants (follicular, oxyphilic and diffuse sclerosing) showed more elevated values in area, perimeter and nuclear range, while, papillary carcinoma, in its classical variant, showed a high value in shape factor. The correlation study between studied variables did not showed similarity in its results in both histological variants.