Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy
oleh: Wenguang Wang, Yuhao Cheng, Peng Yu, Haoran Wang, Yue Zhang, Haiheng Xu, Qingsong Ye, Ahu Yuan, Yiqiao Hu, Jinhui Wu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
Hypoxia-based agents need permeable and hypoxic intratumour environment to be effective. Here, the authors show that perfluorocarbon nanoparticles promote increased permeability and sustained hypoxia to improve accumulation of hypoxia-based agents, and inhibit intratumour oxygen reperfusion.