Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
oleh: A. S. Axelsson, T. Mahdi, H. A. Nenonen, T. Singh, S. Hänzelmann, A. Wendt, A. Bagge, T. M. Reinbothe, J. Millstein, X. Yang, B. Zhang, E. G. Gusmao, L. Shu, M. Szabat, Y. Tang, J. Wang, S. Salö, L. Eliasson, I. Artner, M. Fex, J. D. Johnson, C. B. Wollheim, J.M.J. Derry, B. Mecham, P. Spégel, H. Mulder, I.G. Costa, E. Zhang, A. H. Rosengren
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
Type 2 diabetes (T2D) is a heterogeneous disorder characterized by insulin resistance and impaired insulin secretion. Here Axelssonet al. show that Sox5, which is reduced in diabetes, regulates a set of differentially expressed genes in T2D and its genetic and pharmacological induction improves insulin secretion by diabetic islets.