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To study the stability of a transition section of a tunnel from soft to hard surrounding rock under seepage conditions, FLAC3D software was used to numerically simulate the transition section of the Laomushan Tunnel from the Shiqian to Yuping (Dalong) Expressways in Guizhou Province, China, and to explore different working conditions. The characterization of the tunnel seepage field, stress field, and displacement field and the analysis of the force of the primary lining support structure describe the influence of the seepage field on the stress field distribution and displacement field changes. The reliability of the calculation results is verified by comparison with displacement measurements collected during field monitoring. The design values of the primary support structure parameters of the transition section from soft to hard surrounding rock of the Laomushan Tunnel basically met the strength requirements. The research results provide references for the design and construction of similar projects.