DNA end resection requires constitutive sumoylation of CtIP by CBX4
oleh: Isabel Soria-Bretones, Cristina Cepeda-García, Cintia Checa-Rodriguez, Vincent Heyer, Bernardo Reina-San-Martin, Evi Soutoglou, Pablo Huertas
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-07-01 |
Deskripsi
The choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery. Here the authors show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.