Astrocytic GABA transporter activity modulates excitatory neurotransmission
oleh: Kim Boddum, Thomas P. Jensen, Vincent Magloire, Uffe Kristiansen, Dmitri A. Rusakov, Ivan Pavlov, Matthew C. Walker
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-11-01 |
Deskripsi
Astrocytes monitor and regulate both excitatory and inhibitory synaptic activity. Here, the authors identify a novel form of neuronal-glia communication, by which astrocytes detect rises in GABA via the GABA transporter GAT-3; this results in adenosine release that acts presynaptically to inhibit neural glutamatergic signalling.