(+)-N-(2-Hydroxypropyl)lindcarpine: A New Cytotoxic Aporphine Isolated from Actinodaphne pruinosa Nees
oleh: A. Hamid A. Hadi, Hanita Omar, Khalijah Awang, Marc Litaudon, Hiroshi Morita, Soleh Kosela, Muhammad Hanafi, Mat Ropi Mukhtar, Mohd Azlan Nafiah, Tiah Rachmatiah
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2009-07-01 |
Deskripsi
Onenewalkaloid; (+)-N-(2-hydroxypropyl)lindcarpine (1),together with four known aporphine alkaloids, (+)-boldine (2) (+)-norboldine (3), (+)-lindcarpine (4) and (+)-methyllindcarpine (5) were isolated from the stem bark of Actinodaphne pruinosa Nees (Lauraceae). (+)-N-(2-Hydroxypropyl)lindcarpine (1) exhibited cytotoxic activity against P-388 murine leukemia cells with an IC50 value of 3.9 μg/mL. Structural elucidation of all the compounds were performed by spectral methods such as 1D- and 2D- NMR, IR, UV, and HRESIMS.