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Effect of probiotics and synbiotics consumption based on microbiota of human gut was carried out in our in vivo study. Three groups, P (consuming probiotics), S (consuming synbiotics) and C (control group) of 22 healthy adults were used for this experiment. P and S groups had 10 days long adaptation phase without consuming probiotics and consequently they consumed yoghurt for another 21 days. Control group did not consume yoghurt during the experiment. Faecal samples were collected 10th day of the adaptation phase and then 7, 14 and 21th day of yoghurt consumption phase and finally 26 and 28th day of wash out period. We registered different effect of probiotics and synbiotics on Clostridium sp. and Escherichia coli (E. coli) counts in human digestive system. Consumption of probiotics decreased of E. coli count and consumption of synbiotics increased of both E. coli count and Clostridium sp. in human digestive system.