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Diagnosis and treatment of psychiatric disorders has changed significantly over years. Our understanding of aetiology of psychiatric disorders has evolved from demonic possession to specific neurobiological mechanism. With the continuous growth in the knowledge of aetiology and advancement in medical technologies, the treatment too has progressed from removal of major parts of brain to targeting specific neurotransmitter and receptor. The present article highlights a brief history of psychosurgery which is currently an uncommon mode of treatment.