Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines
oleh: Hongnan Sun, Binbin Huang, Run Lin, Chao Yang, Wujiong Xia
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2015-04-01 |
Deskripsi
The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.