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OBJECTIVE: The aim of this study was to determine the relationship between clinical variables related to patients hospitalized with depression. METHODS: The files of patients hospitalized with depression were examined. Sociodemographic characteristics, clinical features and imaging reports were considered. Data for statistical analysis was obtained only from files that provided clear information. RESULTS: The appropriate treatment for anxiety and psychotic symptoms had a significant effect on response in depression. The presence of non-specific structural cerebral pathologies had an important relationship with the length of hospitalization and suicidal ideation. CONCLUSIONS: Depression is a disorder of which cause, course and outcome has been determined by several different factors. Therefore, addressing depression in a holistic manner is extremely important.