NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes.
oleh: Yao Yao
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2023-07-01 |
Deskripsi
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.