Deubiquitylating enzymes in neuronal health and disease
oleh: Fatima Amer-Sarsour, Alina Kordonsky, Yevgeny Berdichevsky, Gali Prag, Avraham Ashkenazi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Publishing Group 2021-01-01 |
Deskripsi
Abstract Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.