PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells
oleh: Mari Kaarbø, Øyvind Løveseter Mikkelsen, Lene Malerød, Su Qu, Viola H. Lobert, Gulcan Akgul, Thomas Halvorsen, Gunhild M. Mælandsmo, Fahri Saatcioglu
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2010-01-01 |
Deskripsi
Background: Androgen receptor (AR) and the phosphatidylinositol-3 kinase (PI3K) signaling are two of the most important pathways implicated in prostate cancer. Previous work has shown that there is crosstalk between these two pathways; however, there are conflicting findings and the molecular mechanisms are not clear. Here we studied the AR–PI3K pathway crosstalk in prostate cancer cells in vitro as well as in vivo.