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A simple one-pot approach was developed for the synthesis of furan-2(5<i>H</i>)-one derivative containing indole fragments. This method includes the telescoped multicomponent reaction of indole, 4-methoxyphenylglyoxal, and Meldrum’s acid. The synthetic utility of the prepared furan-2(5<i>H</i>)-one was demonstrated by condensation with 4-methoxybenzaldehyde. The advantages of this method include the employment of readily accessible starting materials, atom economy, process simplicity, and the easy isolation of the target products. The structure of the synthesized furanones was confirmed by ¹H and ¹³C-NMR spectroscopy and high-resolution mass spectrometry with electrospray ionization (ESI-HRMS).