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With the wide application of advanced information technology and intelligent equipment in the manufacturing system, the decisions of design and operation have become more interdependent and their integration optimization has gained great concerns from the community of operational research recently. This article investigates an optimization problem of integrating dynamic resource allocation and production schedule in a parallel machine environment. A meta-heuristic algorithm, in which heuristic-based partition, genetic-based sampling, promising index calculation, and backtracking strategies are employed, is proposed for solving the investigated integration problem in order to minimize the makespan of the manufacturing system. The experimental results on a set of random-generated test instances indicate that the presented model is effective and the proposed algorithm exhibits the satisfactory performance that outperforms two state-of-the-art algorithms from literature.