Supramolecular latching system based on ultrastable synthetic binding pairs as versatile tools for protein imaging
oleh: Kyung Lock Kim, Gihyun Sung, Jaehwan Sim, James Murray, Meng Li, Ara Lee, Annadka Shrinidhi, Kyeng Min Park, Kimoon Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-04-01 |
Deskripsi
Although protein-ligand pairs are useful tools for bioimaging, they are susceptible to enzymatic degradation and interference from endogenous species. Here, the authors show that a synthetic and bioorthogonal cucurbit[7]uril-guest binding pair can be used to visualize proteins in cells, overcoming limitations of protein-based platforms.