Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth
oleh: Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L. Vincent, Max Löhning
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
The study shows that mechanical forces trigger secretion of the extracellular matrix protein dentin matrix protein 1 from osteoblasts. This transforms bone growth-promoting blood vessels into a quiescent subtype to limit bone growth at the end of adolescence.