PSPC1-interchanged interactions with PTK6 and β-catenin synergize oncogenic subcellular translocations and tumor progression
oleh: Yaw-Dong Lang, Hsin-Yi Chen, Chun-Ming Ho, Jou-Ho Shih, En-Chi Hsu, Roger Shen, Yu-Ching Lee, Jyun-Wei Chen, Cheng-Yen Wu, Hsi-Wen Yeh, Ruey-Hwa Chen, Yuh-Shan Jou
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-12-01 |
Deskripsi
PSPC1 has a critical role in promoting EMT and metastasis. Here, the authors demonstrate that PSPC1 is the contextual determinant of the oncogenic switch of PTK6/β-catenin subcellular localizations to drive metastasis of hepatocellular carcinoma cells via a PSPC1/PTK6/β-catenin signaling.