Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
oleh: Kristine Williams, Lars R. Ingerslev, Jette Bork-Jensen, Martin Wohlwend, Ann Normann Hansen, Lewin Small, Rasmus Ribel-Madsen, Arne Astrup, Oluf Pedersen, Johan Auwerx, Christopher T. Workman, Niels Grarup, Torben Hansen, Romain Barrès
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Obesity and type 2 diabetes (T2D) are metabolic disorders characterized by insulin resistance in skeletal muscle. Here, the authors map skeletal muscle enhancer elements dynamically regulated after exposure to free fatty acid palmitate or inflammatory cytokine TNFα and identify target genes involved in metabolic dysfunction in skeletal muscle.