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It is well known that algogenic tissue substances (bradykinin, prostaglandins, histamine, serotonin, Substance P) are found in tissues under normal conditions in very small quantities. Cellular, vascular and nerve fiber aggression, especially inflammatory, but also mechanical -traumatic or ischemic of the oro-maxillary tissues causes the concentration of these algogenic factors to increase, inducing the stimulation of algo-conductive nerve pathways. Their presence in large quantities generates the appearance of violent pain sometimes, either through the irritating action they have on the peripheral endings, or through compression edema due to vasodilation and vascular hyperpermeabilization following tissue irritation or aggression. Current review whants to present the potential biomarkers involved in oro-facial pain by analyzing various biofluids different molecular markers who can used to identify the risk factors and predicting the progression and outcomes of painful oro-facial conditions.