Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
oleh: Raquel Chamorro-Garcia, Carlos Diaz-Castillo, Bassem M. Shoucri, Heidi Käch, Ron Leavitt, Toshi Shioda, Bruce Blumberg
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-12-01 |
Deskripsi
Early life exposure to endocrine disrupting chemicals has been linked to increased adiposity during adulthood. Here Chamorro-García et al. show that ancestral exposure to the obesogen tributyltin causes obesity in untreated F4 generation male descendants by inducing heritable changes in genome architecture that promote a thrifty phenotype.