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Pirfenidone is a novel antifibrotic agent that has shown potential in numbers of models and clinical trials. Pirfenidone could inhibit cells proliferation through down-regulating a series of cytokines. Pirfenidone's antifibrotic effect and its safety have been established in organs such as liver, kidney and lung. Current application especially the department of ophthalmology and future researches on Pirfenidone were summarized in this literature.