SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (<i>Rousettus aegyptiacus</i>)
oleh: Neeltje van Doremalen, Alexandra Schäfer, Vineet D. Menachery, Michael Letko, Trenton Bushmaker, Robert J. Fischer, Dania M. Figueroa, Patrick W. Hanley, Greg Saturday, Ralph S. Baric, Vincent J. Munster
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2018-12-01 |
Deskripsi
Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from <i>Rhinolophus sinicus</i> bats and can use the human angiotensin converting enzyme 2 (ACE2) receptor. In the current study, we investigate the ability of WIV1-CoV to infect <i>Rousettus aegyptiacus</i> bats. No clinical signs were observed throughout the experiment. Furthermore, only four oropharyngeal swabs and two respiratory tissues, isolated on day 3 post inoculation, were found positive for viral RNA. Two out of twelve bats showed a modest increase in coronavirus specific antibodies post challenge. In conclusion, WIV1-CoV was unable to cause a robust infection in <i>Rousettus aegyptiacus</i> bats.