Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
oleh: Brunilde Gril, Anurag N. Paranjape, Stephan Woditschka, Emily Hua, Emma L. Dolan, Jeffrey Hanson, Xiaolin Wu, Wojciech Kloc, Ewa Izycka-Swieszewska, Renata Duchnowska, Rafał Pęksa, Wojciech Biernat, Jacek Jassem, Naema Nayyar, Priscilla K. Brastianos, O. Morgan Hall, Cody J. Peer, William D. Figg, Gary T. Pauly, Christina Robinson, Simone Difilippantonio, Emilie Bialecki, Philippe Metellus, Joel P. Schneider, Patricia S. Steeg
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-07-01 |
Deskripsi
When brain metastases form, the blood–brain barrier morphs into the blood–tumor barrier (BTB), surrounded by neuroinflammatory response. Here, the authors show that S1P3 is upregulated in neuroinflammatory response in highly BTB permeable lesions, and modulation of S1P3 could impact BTB permeability.