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We report a case of a 26-year old lady who presented with a history of several episodes of limb weakness requiring repeated hospitalization over the last 12 years and about 6 years back, she also developed features of sicca complex. Further investigations revealed hypokalemia, distal renal tubular acidosis and bilateral extensive nephrocalcinosis. Finally, a diagnosis of Sjogren’s syndrome was made. Hypokalemia may be the presenting feature of Sjogren’s syndrome. Sjogren’s syndrome may be suspected in patients with recurrent hypokalemia and renal tubular acidosis. IMC J Med Sci 2022; 16(2): 004. DOI: https://doi.org/10.55010/imcjms.16.014 *Correspondence: Shapur Ikhtaire, Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh. Email: shapur17@gmail.com