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To assess the effect of aqueous extract of <i>Carum carvi</i> seeds in experimentally induced diabetic nephropathy (DN) in rodents, we studied 48 adult male Wistar rats divided into 4 groups: normal controls (group A), diabetes positive control (group B), and experimental (groups C and D). They received <i>Carum carvi</i> extract as a renoprotective agent. Rats having fasting blood glucose levels over 280 mg/dL were included in this study. Group C rats received STZ (60 mg/kg) and aqueous extract of <i>Carum carvi</i> at 30 mg/kg of body weights. On the other hand group D rats received STZ (60 mg/kg) and aqueous extract of <i>Carum carvi</i> at 60 mg/kg of body weight. Blood samples were collected on the 60 ^th day, and kidneys were also extracted for examination. The diabetic group rats showed a variable increase in the serum levels of glucose, urea, creatinine, total urinary protein and microalbuminuric levels. Body weight decreased and urine volume increased in the diabetic groups. 30 mg/kg body weight of <i>Carum carvi</i> dose decreased the levels of these parameters in rats. On the other hand, 60 mg/kg body weight of <i>Carum carvi</i> dose significantly decreased the levels of the biochemical parameters. The morphological examination of group C rats showed no changes whereas the rats in group D showed moderate changes. <i>Carum carvi</i> constituents, especially flavonoids and carvone have strong anti-oxidant activity, which provides reno-protection against diabetes and its complications. In conclusion, high dose of <i>Carum carvi</i> aqueous seeds extract (60 mg/kg) showed reno-protection against STZ induced dia-betic nephropathy in rats.