Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
oleh: Yawei Wang, Binlin Tang, Lei Long, Peng Luo, Wei Xiang, Xueru Li, Huilan Wang, Qingzhi Jiang, Xu Tan, Shenglin Luo, Huijuan Li, Ziwen Wang, Zelin Chen, Yu Leng, Zhongyong Jiang, Yang Wang, Le Ma, Rui Wang, Chunyu Zeng, Zujuan Liu, Yu Wang, Hongming Miao, Chunmeng Shi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Adipose tissue macrophages are central to controlling inflammation in the context of obesity. Here the authors present a new infrared dye (IR-61) that accumulates in the mitochondria of these cells resulting in anti-inflammatory effects that counter obesity-associated pathology in mice.