Marrying chemistry with biology by combining on-chip solution-based combinatorial synthesis and cellular screening
oleh: Maximilian Benz, Mijanur R. Molla, Alexander Böser, Alisa Rosenfeld, Pavel A. Levkin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-06-01 |
Deskripsi
High-throughput cell-based screening of compound libraries is utilised in drug development; however, a lack of compatible methods limits direct synthesis and testing. Here, the authors present a diverse chip based synthesis system which can be combined with cell screening and demonstrate the application.