Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens
oleh: Kinneret Rozales, Amal Younis, Naseeb Saida, Anatoly Meller, Hodaya Goldman, Lior Kellerman, Ronit Heinrich, Shai Berlin, Reut Shalgi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
Here, using quantitative screens in human cells, the authors reveal distinct effects of naturally-occurring DNAJ chaperone isoforms on pathological aggregation of the Huntington’s disease-associated HTT-polyQ and the ALS-related mutant FUS.