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The investigation evaluated the capability of the mathematical model proposed by Pérez (2010) to describe poly-dispersion in hydro-mixtures for diverse cases of grain size frequency distributions. The efficacy of the model was assessed when investigating the raw materials required by the acid leach process to produce nickel sulphides: laterite slurries and calcium carbonate mud. The experimental grain size analysis was conducted by implementing two techniques: conventional screening and particle size analyzer (HORIBA). The results obtained from the application of computer-based techniques to generate mathematical models show that the model is capable to describe poly-dispersion in hydro-mixtures. It was concluded that poly-dispersion in calcium carbonate mud is higher than in laterite slurries.