A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant
oleh: Cai He, Jingyun Yang, Weiqi Hong, Zimin Chen, Dandan Peng, Hong Lei, Aqu Alu, Xuemei He, Zhenfei Bi, Xiaohua Jiang, Guowen Jia, Yun Yang, Yanan Zhou, Wenhai Yu, Cong Tang, Qing Huang, Mengli Yang, Bai Li, Jingmei Li, Junbin Wang, Haiying Que, Li Chen, Wenyan Ren, Dandan Wan, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Zhaoming Su, Yuquan Wei, Xiaobo Cen, Yoshimasa Tanaka, Xiangrong Song, Shuaiyao Lu, Xiaozhong Peng, Guangwen Lu, Xiawei Wei
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
The SARS-CoV-2 Omicron variant has quickly become the predominant circulating variant, due to the high transmissibility and immune escape. Here, the authors develop a trimeric protein vaccine candidate and show a sustained humoral immune response, and protection from challenge (Omicron and Delta) in various animal models.