Penigrisacids A–D, Four New Sesquiterpenes from the Deep-Sea-Derived <i>Penicillium griseofulvum</i>
oleh: Cui-Ping Xing, Chun-Lan Xie, Jin-Mei Xia, Qing-Mei Liu, Wei-Xiang Lin, De-Zan Ye, Guang-Ming Liu, Xian-Wen Yang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-08-01 |
Deskripsi
Four new (penigrisacids A−D, <b>1</b>−<b>4</b>) and one known (<b>5</b>) carotane sesquiterpenoids were isolated from the deep-sea-derived fungus <i>Penicillium griseofulvum</i>, along with four known compounds (<b>6</b>−<b>9</b>). The planar structures and relative configurations of the new compounds were determined by extensive analysis of the NMR and HRESIMS data. The absolute configurations were established by comparison of the experimental and calculated ECD (electronic circular dichroism) spectra or OR (optical rotation) value. Compound <b>9</b> exhibited potent anti-food allergic activity with IC<sub>50</sub> value of 28.7 μM, while <b>4</b> showed weak cytotoxicity against ECA-109 tumor cells (IC<sub>50</sub> = 28.7 μM).